Article
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia.
Die Pharmazie - 30 Dec 2024
Bagher A M, Alkhaldi M F, Somaily J A, Altheyab D A, Khafaji M A, Awad R F, Eid B G, Binmahfouz L S
Abstract excerpt
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating mental disorder that has been linked to hyperhomocysteinemia and folate deficiency. These conditions are influenced by the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in converting homocysteine to methionine and is essential for folate metabolism and neurotransmitter synthesis, including serotonin. Study...
Topics
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Major Depressive Disorder
- Saudi Arabia
- Female
- Male
- Adult
- Genotype
- Middle Aged
- Genetic Predisposition to Disease