Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA polymerase mu, a candidate hypermutase?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Ruiz J F, Domínguez O, Laín de Lera T, Garcia-Díaz M, Bernad A, Blanco L

Abstract excerpt

A novel DNA polymerase (Pol mu) has been recently identified in human cells. The amino-acid sequence of Pol mu is 42% identical to that of terminal deoxynucleotidyl transferase (TdT), a DNA-independent DNA polymerase that contributes to antigen-receptor diversity. In this paper we review the evidence supporting the role of Pol mu in somatic hypermutation of immunoglobulin genes, a T-dependent process that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA Nucleotidylexotransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Germinal Center

Share to Lymphocytes

Share to Protein Conformation

Share to Recombination, Genetic

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11205337
DOI: 10.1098/rstb.2000.0754
PMCID: PMC1087697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA polymerase mu, a candidate hypermutase?PMID 11205337Read ↗

DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.Semantic proximity Read ↗

Overexpression of human DNA polymerase (Pol ) in a Burkitt's lymphoma cell line affects the somatic hypermutation rateSemantic proximity Read ↗

Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu.Semantic proximity Read ↗

Transcription, beta-like DNA polymerases and hypermutation.Semantic proximity Read ↗

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

Somatic mutation patterns at Ig and Non-Ig Loci.Semantic proximity Read ↗

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.Semantic proximity Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.Semantic proximity Read ↗

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.Semantic proximity Read ↗

An update on the role of translesion synthesis DNA polymerases in Ig hypermutation.Semantic proximity Read ↗

DNA polymerase η mutational signatures are found in a variety of different types of cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.