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Article

Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.

Molecular genetics and genomics : MGG - 1 Feb 2011

Villa-García Manuel J, Choi Myung Sun, Hinz Flora I, Gaspar María L, Jesch Stephen A, Henry Susan A

Abstract excerpt

Inositol auxotrophy (Ino(-) phenotype) in budding yeast has classically been associated with misregulation of INO1 and other genes involved in lipid metabolism. To identify all non-essential yeast genes that are necessary for growth in the absence of inositol, we carried out a genome-wide phenotypic screening for deletion mutants exhibiting Ino(-) phenotypes under one or more growth conditions. We report the...

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Topics

Genome-Wide Association Study
Inositol
Lipid Metabolism
Mutation
Phenotype
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Signal Transduction

Stress, Physiological

Source

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Identifiers

PMID: 21136082
DOI: 10.1007/s00438-010-0592-x
PMCID: PMC3037835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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