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Article

Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast.

The Journal of biological chemistry - 21 May 2004

Ju Shulin, Shaltiel Galit, Shamir Alon, Agam Galila, Greenberg Miriam L

Abstract excerpt

We have cloned, sequenced, and expressed a human cDNA encoding 1-d-myo-inositol-3-phosphate (MIP) synthase (hINO1). The encoded 62-kDa human enzyme converted d-glucose 6-phosphate to 1-d-myo-inositol 3-phosphate, the rate-limiting step for de novo inositol biosynthesis. Activity of the recombinant human MIP synthase purified from Escherichia coli was optimal at pH 8.0 at 37 degrees C and exhibited K(m) values of...

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Identifiers

PMID: 15024000
DOI: 10.1074/jbc.M312078200

Genes

MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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