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Sirtuin deacetylases in neurodegenerative diseases of aging

21 May 2013

Abstract excerpt

Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins have been linked with caloric restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Sirtuin enzymes are potential therapeutic targets in a variety of human diseases...

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PMID: 23689277
DOI: 10.1038/cr.2013.70

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