Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models.

Vaccine - 8 May 2006

Saravia Nancy Gore, Escorcia Blanca, Osorio Yaneth, Valderrama Liliana, Brooks Darren, Arteaga Lourdes, Coombs Graham, Mottram Jeremy, Travi Bruno Luis

Abstract excerpt

This study demonstrates that deletion of cysteine proteinase (CP) genes diminishes pathogenicity of Leishmania mexicana in non-murine experimental host models while preserving immunogenicity. Both cpb and cpa/cpb-deficient lines induced delayed disease onset, smaller lesions and lower parasite burden in hamsters. cpa/cpb-deficient L. mexicana grew more slowly as promastigotes and presented lower infectivity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cricetinae
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Protozoan

Share to In Vitro Techniques

Share to Leishmania

Share to Leishmaniasis, Cutaneous

Share to Mesocricetus

Share to Protozoan Vaccines

Source

Identifiers

PMID: 16216395
DOI: 10.1016/j.vaccine.2005.05.045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models.PMID 16216395Read ↗

<i>Leishmania mexicana</i> Cysteine Proteinase-Deficient Mutants Have Attenuated Virulence for Mice and Potentiate a Th1 ResponseSemantic proximity Read ↗

Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo.Semantic proximity Read ↗

Cysteine Protease B of <i>Leishmania mexicana</i> Inhibits Host Th1 Responses and Protective ImmunitySemantic proximity Read ↗

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.Semantic proximity Read ↗

Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana.Semantic proximity Read ↗

Proteinases as virulence factors in Leishmania spp. infection in mammalsSemantic proximity Read ↗

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasisSemantic proximity Read ↗

Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus syrian hamster modelSemantic proximity Read ↗

Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.Semantic proximity Read ↗

Leishmania species: models of intracellular parasitismSemantic proximity Read ↗

Th1 and Th2 immunological profile induced by cysteine proteinase in murine leishmaniasis.Semantic proximity Read ↗

Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.