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Article

Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana.

Molecular and biochemical parasitology - 1 Sept 1997

Bart G, Frame M J, Carter R, Coombs G H, Mottram J C

Abstract excerpt

Mutants null for the cathepsin B-like cysteine proteinase gene (cpc) of Leishmania mexicana have been generated by targeted gene disruption. The gene deletion was confirmed using a polymerase chain reaction (PCR) method with cpc-specific primers and genomic DNA isolated from the mutants. cpc was re-expressed in the null mutants from an episomal vector. Re-expression of the enzyme (CPC) was detected by Western...

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PMID: 9274867
DOI: 10.1016/s0166-6851(97)00072-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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