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Article

Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo.

Infection and immunity - 1 Jun 2003

Denise Hubert, McNeil Kathryn, Brooks Darren R, Alexander James, Coombs Graham H, Mottram Jeremy C

Abstract excerpt

Leishmania mexicana mutants deficient in the multicopy CPB gene array have reduced virulence, demonstrated by poor lesion growth in BALB/c mice and induction of a protective Th1 response. Reinsertion of the amastigote-specific CPB2.8 or metacyclic stage-specific CPB2 gene into a CPB-deficient mutant L. mexicana failed to restore either a Th2 response or sustained virulence. However, reexpression of multiple CPB...

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Source

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Identifiers

PMID: 12761098
DOI: 10.1128/IAI.71.6.3190-3195.2003
PMCID: PMC155739

Genes

CPB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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