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Article

Cysteine Protease B of <i>Leishmania mexicana</i> Inhibits Host Th1 Responses and Protective Immunity

1 Oct 2003

Abstract excerpt

C3H mice infected with Leishmania mexicana fail to develop a protective Th1 response, and are unable to cure. In this study, we show that L. mexicana cysteine proteases suppress the antileishmanial immune response. Previous studies demonstrated that deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virulence, potentially attributable to...

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Identifiers

PMID: 14500670
DOI: 10.4049/jimmunol.171.7.3711

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