Article
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.
BMC molecular biology - 13 Nov 2006
Denise Hubert, Poot Jacqueline, Jiménez Maribel, Ambit Audrey, Herrmann Daland C, Vermeulen Arno N, Coombs Graham H, Mottram Jeremy C
Abstract excerpt
BACKGROUND: Visceral leishmaniasis caused by members of the Leishmania donovani complex is often fatal in the absence of treatment. Research has been hampered by the lack of good laboratory models and tools for genetic manipulation. In this study, we have characterised a L. infantum line (JPCM5) that was isolated from a naturally infected dog and then cloned. We found that JPCM5 has attributes that make it an...
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