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Article

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996

Mottram J C, Souza A E, Hutchison J E, Carter R, Frame M J, Coombs G H

Abstract excerpt

The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be cultured in vitro, demonstrating that the gene is not essential for growth or differentiation of the parasite. However, the...

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PMID: 8650210
DOI: 10.1073/pnas.93.12.6008
PMCID: PMC39179

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Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.PMID 8650210Read ↗

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