Article
Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis
2020-11-20
Abstract excerpt
Visceral Leishmaniasis (VL) is fatal if untreated. There is no licensed vaccine available against human leishmaniasis. We recently demonstrated protection in mice against L. major infection using a CRISPR genome edited attenuated Leishmania major strain ( LmCen −/− ). Here, as a pre-clinical step, we evaluated the protective efficacy of LmCen −/− against VL induced by sand fly transmitted Leishmania donovani...
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Identifiers and source
- Literature Corpus work
- 315e02b3-b367-5f5d-ba71-c9c201fe9f10
- DOI
- 10.1101/2020.11.18.388553