Article
Th1 and Th2 immunological profile induced by cysteine proteinase in murine leishmaniasis.
Parasite immunology - 1 Mar 2004
Alves C R, Benévolo-De-Andrade T C, Alves J L, Pirmez C
Abstract excerpt
This study evaluated the immune response to three synthetic peptides (pI, VMVEQVICFD; pII, VGGGLCFE; pIII, PYFLGSIMNTCHYT) from the COOH-terminal region of Leishmania amazonensis cysteine proteinases, in BALB/c- and CBA-infected mice with this parasite. Only BALB/c mice, previously inoculated with pI, showed a distinct exacerbation of the lesion. Blastogenesis assays were performed with lymph node cells from the...
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