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Article

Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability.

Biophysical journal - 19 May 2010

Ambrosi Cinzia, Boassa Daniela, Pranskevich Jennifer, Smock Amy, Oshima Atsunori, Xu Ji, Nicholson Bruce J, Sosinsky Gina E

Abstract excerpt

Connexin26 is a ubiquitous gap junction protein that serves critical homeostatic functions. Four single-site mutations found in the transmembrane helices (M1-M4) cause different types of dysfunctional channels: 1), Cx26T135A in M3 produces a closed channel; 2), Cx26M34A in M1 severely decreases channel activity; 3), Cx26P87L in M2 has been implicated in defective channel gating; and 4), Cx26V84L in M2, a...

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Identifiers

PMID: 20441744
DOI: 10.1016/j.bpj.2010.01.019
PMCID: PMC2862186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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