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Article

The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.

Cellular signalling - 1 Jul 2006

Sambi Balwinder S, Hains Melinda D, Waters Catherine M, Connell Michelle C, Willard Francis S, Kimple Adam J, Pyne Susan, Siderovski David P, Pyne Nigel J

Abstract excerpt

We have previously shown that the PDGFbeta receptor uses a classical GPCR-mediated pathway in order to induce efficient activation of p42/p44 MAPK in response to PDGF. We therefore, considered the possibility that GTPase accelerating proteins (RGS proteins), which regulate GPCR signalling, modulate PDGFbeta receptor-mediated signal transmission. Several lines of evidence were obtained to support functional...

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Source

Identifiers

PMID: 16214305
DOI: 10.1016/j.cellsig.2005.08.003

Genes

RGS12
RGS14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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