Article
Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection.
Molecular immunology - 1 Mar 2006
Vallinoto Antonio Carlos Rosário, Menezes-Costa Marcos Rogério, Alves Anna Elizabeth Martins, Machado Luiz Fernando Almeida, de Azevedo Vânia Nakauth, Souza Lia Lobato Batista, Ishak Marluísa de Oliveira Guimarães, Ishak Ricardo
Abstract excerpt
Mannose-binding lectin (MBL) is a serum protein whose low concentration is associated with the occurrence of allele variants named MBL*B, MBL*C and MBL*D. The present study investigated the association between MBL gene polymorphism and the susceptibility to HIV-1 infection. The study of 145 HIV-1-infected subjects and 99 healthy controls showed the presence of alleles MBL*A, MBL*B and MBL*D, whose frequencies...
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