Article
Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin.
Lancet (London, England) - 25 Jan 1997
Garred P, Madsen H O, Balslev U, Hofmann B, Pedersen C, Gerstoft J, Svejgaard A
Abstract excerpt
BACKGROUND: Low serum concentrations of mannose-binding lectin (MBL) are associated with increased susceptibility to recurrent infection. Three variant alleles in the MBL gene (B, C, and D), cause low serum concentrations of the protein. We investigated whether variant alleles of MBL affect susce...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Alleles
- CD4 Lymphocyte Count
- Carrier Proteins
- Collectins
- Disease Progression
- Genetic Predisposition to Disease
- Genetic Variation
- HIV Infections
- Homosexuality, Male
- Humans
- Lectins
- Male
- Mannans
- Middle Aged
- Multivariate Analysis
- Survival Rate