Article
The role of mannose-binding lectin gene polymorphisms in susceptibility to HIV-1 infection in Southern Brazilian patients.
AIDS (London, England) - 20 Feb 2011
da Silva Gabriela Kniphoff, Guimarães Rafael, Mattevi Vanessa Suñé, Lazzaretti Rosmeri Kuhmmer, Sprinz Eduardo, Kuhmmer Regina, Brandão Lucas, Crovella Sérgio, Chies José Artur Bogo
Abstract excerpt
OBJECTIVE: This study investigates the role of mannose-binding lectin (MBL) in the susceptibility to HIV-1 infection analyzing polymorphisms located at the MBL2 promoter and exon 1 regions. MATERIALS AND METHODS: The prevalence of MBL2 variant alleles was investigated in 410 HIV-1-infected patients from the South Brazilian HIV cohort and in 345 unexposed uninfected healthy individuals. The promoter variants were...
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