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Article

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2005

Zhang Xuchen, Shan Peiying, Qureshi Salman, Homer Robert, Medzhitov Ruslan, Noble Paul W, Lee Patty J

Abstract excerpt

TLRs have been studied extensively in pathogen-mediated host responses. We use a murine model of lethal oxidant-mediated injury to demonstrate for the first time that mammalian TLR4 is required for survival and lung integrity. Administering high levels of inspired oxygen, or hyperoxia, is commonly used as a life-sustaining measure in critically ill patients. However, prolonged exposures can lead to respiratory...

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Source

Identifiers

PMID: 16210584
DOI: 10.4049/jimmunol.175.8.4834

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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