Article

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury

2024-09-19

Abstract excerpt

Bronchopulmonary dysplasia (BPD), a chronic lung disease, is the most common major complication of preterm birth. Supplemental oxygen administration, while lifesaving in the neonatal period, remains a key determinant of BPD pathophysiology. Exposure of the immature lung to increased levels of oxygen elicits an inflammatory response resulting in abnormal lung development. However, not every premature infant is equa...

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Literature Corpus work: 7cbbbdab-2470-5ab1-b9dd-8485b4f70d1b
DOI: 10.1101/2024.09.13.612775

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