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Article

Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology - 1 May 2000

Pryhuber G S, O'Brien D P, Baggs R, Phipps R, Huyck H, Sanz I, Nahm M H

Abstract excerpt

Hyperoxic lung injury, believed to be mediated by reactive oxygen species, inflammatory cell activation, and release of cytotoxic cytokines, complicates the care of many critically ill patients. The cytokine tumor necrosis factor (TNF)-alpha is induced in lungs exposed to high concentrations of oxygen; however, its contribution to hyperoxia-induced lung injury remains unclear. Both TNF-alpha treatment and...

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Source

Identifiers

PMID: 10781441
DOI: 10.1152/ajplung.2000.278.5.L1082

Genes

TNF
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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