Article
Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarction in Japanese.
International journal of cardiology - 1 Dec 2003
Nojiri Takefumi, Morita Hiroyuki, Imai Yasushi, Maemura Koji, Ohno Minoru, Ogasawara Ken, Aizawa Tadanori, Saito Akira, Hayashi Doubun, Hirata Yasunobu, Sugiyama Takao, Yamazaki Tsutomu, Nagai Ryozo
Abstract excerpt
Matrix metalloproteinases (MMPs) are involved in plaque rupture, which is the main pathological cause of myocardial infarction (MI). Recently, several genetic studies have demonstrated that MMP-1 1G/2G polymorphism and MMP-3 5A/6A polymorphism modify each transcriptional activity in allele specific manners. Within this context, we conducted case-control studies to examine whether these genetic polymorphisms are...
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