Article
Dependence of SV40 large T-antigen cell cycle regulation on T-antigen expression levels.
Oncogene - 1 Jul 1992
Sladek T L, Jacobberger J W
Abstract excerpt
Simian virus 40 (SV40) large T antigen (Tag) expression results in reduced percentages of G1-phase cells and increased percentages of S- and G2+M-phase cells in exponentially growing fibroblast populations as compared with identical cell populations not expressing Tag. This effect is the result of reduced G1 and increased G2+M cell cycle phase durations caused by Tag [Sladek, T.L. & Jacobberger, J.W. (1992). J....
Topics
- Antigens, Polyomavirus Transforming
- Cell Cycle
- DNA, Recombinant
- Flow Cytometry
- Fluorescent Antibody Technique
- Gene Expression Regulation, Viral
- Phenotype
- Retroviridae
- Transfection