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Article

Human Cytomegalovirus UL69 Protein Induces Cells To Accumulate in G 1 Phase of the Cell Cycle

1 Jan 1999

Abstract excerpt

Earlier studies have revealed that human cytomegalovirus rapidly inhibits the growth of fibroblasts, blocking cell cycle progression at multiple points, including the G1-to-S-phase transition. The present study demonstrates that the UL69 protein, a virus-encoded constituent of the virion, is able to arrest cell cycle progression when introduced into uninfected cells. Expression of the UL69 protein causes U2 OS...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 9847373
DOI: 10.1128/jvi.73.1.676-683.1999

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Related research

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Research trail→

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Human Cytomegalovirus UL69 Protein Induces Cells To Accumulate in G 1 Phase of the Cell CyclePMID 9847373Read ↗

Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle.Semantic proximity Read ↗

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The Human Cytomegalovirus IE86 Protein Can Block Cell Cycle Progression after Inducing Transition into the S Phase of Permissive CellsSemantic proximity Read ↗

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UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression.Semantic proximity Read ↗

Requirement for Uracil-DNA Glycosylase during the Transition to Late-Phase Cytomegalovirus DNA ReplicationSemantic proximity Read ↗

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The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.Semantic proximity Read ↗

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