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Article

Evolutionary constraints in conserved nongenic sequences of mammals.

Genome research - 1 Oct 2005

Keightley Peter D, Kryukov Gregory V, Sunyaev Shamil, Halligan Daniel L, Gaffney Daniel J

Abstract excerpt

Mammalian genomes contain many highly conserved nongenic sequences (CNGs) whose functional significance is poorly understood. Sets of CNGs have previously been identified by selecting the most conserved elements from a chromosome or genome, but in these highly selected samples, conservation may be unrelated to purifying selection. Furthermore, conservation of CNGs may be caused by mutation rate variation rather...

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Identifiers

PMID: 16204190
DOI: 10.1101/gr.3942005
PMCID: PMC1240079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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