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Article

High genomic deleterious mutation rates in hominids.

Nature - 28 Jan 1999

Eyre-Walker A, Keightley P D

Abstract excerpt

It has been suggested that humans may suffer a high genomic deleterious mutation rate. Here we test this hypothesis by applying a variant of a molecular approach to estimate the deleterious mutation rate in hominids from the level of selective constraint in DNA sequences. Under conservative assumptions, we estimate that an average of 4.2 amino-acid-altering mutations per diploid per generation have occurred in...

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PMID: 9950425
DOI: 10.1038/16915

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