High genomic deleterious mutation rates in hominids.

doi:10.1038/16915

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Article

High genomic deleterious mutation rates in hominids.

Nature - 28 Jan 1999

Eyre-Walker A, Keightley P D

Abstract excerpt

It has been suggested that humans may suffer a high genomic deleterious mutation rate. Here we test this hypothesis by applying a variant of a molecular approach to estimate the deleterious mutation rate in hominids from the level of selective constraint in DNA sequences. Under conservative assum...

Topics

Animals
Evolution, Molecular
Gene Frequency
Hominidae
Humans
Mutation
Pan troglodytes
Proteins
Reproduction

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