Article
Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis.
Circulation - 20 Feb 2007
Kjaergaard Alisa D, Ellervik Christina, Tybjaerg-Hansen Anne, Axelsson Christen Kirk, Grønholdt Marie-Louise M, Grande Peer, Jensen Gorm B, Nordestgaard Børge G
Abstract excerpt
BACKGROUND: We hypothesized that the estrogen receptor alpha (ESR1) IVS1-397T/C polymorphism affects high-density lipoprotein cholesterol response to hormone replacement therapy and risk of cardiovascular disease (CVD), cancer of reproductive organs, and hip fracture. METHODS AND RESULTS: We studied cross-sectionally 9244 individuals from the Danish general population and followed them up for 23 to 25 years. End...
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