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Article

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.

The Journal of biological chemistry - 2 Dec 2005

McDonald Christine, Chen Felicia F, Ollendorff Vincent, Ogura Yasunori, Marchetto Sylvie, Lécine Patrick, Borg Jean-Paul, Nuñez Gabriel

Abstract excerpt

Nod2 is an intracellular sensor of a specific bacterial cell wall component, muramyl dipeptide, and activation of Nod2 stimulates an inflammatory response. Specific mutations of Nod2 have been associated with two inflammatory diseases, Crohn disease and Blau syndrome, and are thought to contribute to disease susceptibility through altering Nod2 signaling. Association of disease with inappropriate activation of...

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Identifiers

PMID: 16203728
DOI: 10.1074/jbc.M508538200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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