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Article

Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.

Antimicrobial agents and chemotherapy - 1 Dec 2007

Japrung Deanpen, Leartsakulpanich Ubolsree, Chusacultanachai Sudsanguan, Yuthavong Yongyuth

Abstract excerpt

Plasmodium falciparum strains bearing quadruple mutations of dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) at codons 51, 59, 108, and 164 are highly resistant to pyrimethamine (PYR), a diaminopyrimidine, but sensitive to WR99210 (WR), a cycloguanil analog, suggesting different enzyme-inhibitor binding interactions. A combination of these inhibitors to delay the onset of antifolate resistance is...

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Identifiers

PMID: 17875995
DOI: 10.1128/AAC.00577-07
PMCID: PMC2167985

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