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Article

Mutations in the middle domain of yeast poly(A) polymerase affect interactions with RNA but not ATP.

RNA (New York, N.Y.) - 1 Apr 2004

Zhelkovsky Alexander, Helmling Steffen, Bohm Andrew, Moore Claire

Abstract excerpt

The eukaryotic poly(A) polymerase (PAP) is responsible for the posttranscriptional extension of mRNA 3' ends by the addition of a poly(A) tract. The recently published three-dimensional structures of yeast and bovine PAPs have made a more directed biochemical analysis of this enzyme possible. Based on these structures, the middle domain of PAP was predicted to interact with ATP. However, in this study, we show...

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Identifiers

PMID: 15037764
DOI: 10.1261/rna.5238704
PMCID: PMC1370545

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Source receipt: pubmed, retrieved 7 Sept 2026.

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