Article
Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors.
Journal of the National Cancer Institute - 15 Jul 1992
Lothe R A, Fossli T, Danielsen H E, Stenwig A E, Nesland J M, Gallie B, Børresen A L
Abstract excerpt
BACKGROUND: In the majority of colorectal carcinomas, both copies of the tumor suppressor gene TP53 (tumor protein 53) are known to be inactivated. In contrast to a loss of tumor suppressor function, it has been suggested that an increased copy number of the RB1 gene is involved in the progression of these tumors. PURPOSE: To determine genetic alterations at chromosomes 13 and 17 in colorectal tumors, we have...
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