Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors.

doi:10.1093/jnci/84.14.1100

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Article

Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors.

Journal of the National Cancer Institute - 15 Jul 1992

Lothe R A, Fossli T, Danielsen H E, Stenwig A E, Nesland J M, Gallie B, Børresen A L

Abstract excerpt

BACKGROUND: In the majority of colorectal carcinomas, both copies of the tumor suppressor gene TP53 (tumor protein 53) are known to be inactivated. In contrast to a loss of tumor suppressor function, it has been suggested that an increased copy number of the RB1 gene is involved in the progression of these tumors. PURPOSE: To determine genetic alterations at chromosomes 13 and 17 in colorectal tumors, we have...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
Blotting, Northern
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Codon
Colorectal Neoplasms
DNA Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Neoplasm

Electrophoresis

Female

Gene Expression

Genes, Tumor Suppressor

Genes, p53

Humans

Source

Open in PubMed

Identifiers

PMID: 1619684
DOI: 10.1093/jnci/84.14.1100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1619684-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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