Loss of somatic heterozygosity in hepatocellular carcinoma.

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Article

Loss of somatic heterozygosity in hepatocellular carcinoma.

Cancer research - 15 Aug 1991

Walker G J, Hayward N K, Falvey S, Cooksley W G

Abstract excerpt

Loss of tumor suppressor genes is involved in the mechanism of tumorigenesis of many solid tumors. We tested 9 hepatitis B virus (HBV)-positive and 10 HBV-negative hepatocellular carcinomas for loss of somatic heterozygosity using 14 polymorphic probes mapping to chromosomes 4, 11, 13, and 17. Lo...

Topics

Adult
Aged
Alleles
Carcinoma, Hepatocellular
Chromosome Deletion
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 4
Female
Hepatitis B virus
Heterozygote
Humans
Liver Cirrhosis
Liver Neoplasms
Male
Middle Aged
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1678314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1678314-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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