Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of somatic heterozygosity in hepatocellular carcinoma.

Cancer research - 15 Aug 1991

Walker G J, Hayward N K, Falvey S, Cooksley W G

Abstract excerpt

Loss of tumor suppressor genes is involved in the mechanism of tumorigenesis of many solid tumors. We tested 9 hepatitis B virus (HBV)-positive and 10 HBV-negative hepatocellular carcinomas for loss of somatic heterozygosity using 14 polymorphic probes mapping to chromosomes 4, 11, 13, and 17. Losses were found on all chromosome arms tested. The highest frequency of loss was observed at the D13S1 locus (67%) at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 17

Share to Heterozygote

Share to Liver Neoplasms

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 1678314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of somatic heterozygosity in hepatocellular carcinoma.PMID 1678314Read ↗

Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma.Semantic proximity Read ↗

Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular CarcinomaSemantic proximity Read ↗

Loss of heterozygosity on chromosome 16 in hepatocellular carcinoma.Semantic proximity Read ↗

Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regionsSemantic proximity Read ↗

Clinicopathological significance of loss of heterozygosity on chromosome 13q in hepatocellular carcinoma.Semantic proximity Read ↗

Loss of heterozygosity in chromosome 4q12-q13 in hepatocellular carcinoma in southern African blacks.Semantic proximity Read ↗

Loss of heterozygosity at selective sites on chromosomes 13 and 17 in human breast carcinoma.Semantic proximity Read ↗

Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer.Semantic proximity Read ↗

Molecular genetic changes in human epithelial ovarian malignancies.Semantic proximity Read ↗

Genetic alterations of the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q in human breast carcinomas.Semantic proximity Read ↗

Comprehensive allelotyping of hepatoblastoma.Semantic proximity Read ↗

Comprehensive allelotype study of hepatocellular carcinoma: potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.