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Article

Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.

Human molecular genetics - 1 Nov 2005

Brière Jean-Jacques, Favier Judith, Bénit Paule, El Ghouzzi Vincent, Lorenzato Annalisa, Rabier Daniel, Di Renzo Maria Flavia, Gimenez-Roqueplo Anne-Paule, Rustin Pierre

Abstract excerpt

The genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as tumour suppressors in neuro-endocrine tissues. Tumour formation has been associated with succinate accumulation. In paraganglioma cells, two forms of SDHA (type I, II) were found which might preclude significant succinate accumulation in the case of a mutation in either form. In fibroblasts only SDHA type I is found. In these cells, SDHA...

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Identifiers

PMID: 16195397
DOI: 10.1093/hmg/ddi359

Genes

SDHA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.PMID 16195397Read ↗

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