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Article

Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells.

Biochimica et biophysica acta - 1 Jan 2000

Selak Mary A, Durán Raul V, Gottlieb Eyal

Abstract excerpt

HIFalpha prolyl hydroxylases (PHDs) are a family of enzymes that regulate protein levels of the alpha subunit of the hypoxia inducible transcription factor (HIF) under different oxygen levels. PHDs catalyse the conversion of a prolyl residue, molecular oxygen and alpha-ketoglutarate to hydroxy-prolyl, carbon dioxide and succinate in a reaction dependent on ferrous iron and ascorbate as cofactors. Recently it was...

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Identifiers

PMID: 16797480
DOI: 10.1016/j.bbabio.2006.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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