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Article

Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.

Blood - 1 Feb 2006

Hanaoka Nobuyoshi, Kawaguchi Tatsuya, Horikawa Kentaro, Nagakura Shoichi, Mitsuya Hiroaki, Nakakuma Hideki

Abstract excerpt

The mechanism by which paroxysmal nocturnal hemoglobinuria (PNH) clones expand is unknown. PNH clones harbor PIGA mutations and do not synthesize glycosylphosphatidylinositol (GPI), resulting in deficiency of GPI-linked membrane proteins. GPI-deficient blood cells often expand in patients with aplastic anemia who sustain immune-mediated marrow injury putatively induced by cytotoxic cells, hence suggesting that...

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Share to Anemia, Aplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16195329
DOI: 10.1182/blood-2005-03-1337

Genes

GPI
PIGA
ULBP1
ULBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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