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Article

Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.

Experimental hematology - 1 Dec 2001

Ware R E, Pickens C V, DeCastro C M, Howard T A

Abstract excerpt

OBJECTIVE: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematological disorder with acquired PIG-A gene mutations and absent surface expression of proteins utilizing glycosylphosphatidylinositol (GPI) anchors. PNH often follows aplastic anemia, suggesting PIG-A mutant cells have relative dominance over normal hematopoietic cells. Somatic PIG-A mutations could arise after aplasia, or healthy persons could...

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Source

Identifiers

PMID: 11750098
DOI: 10.1016/s0301-472x(01)00746-9

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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