Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.

Blood - 1 Aug 2002

Nagakura Shoichi, Ishihara Sonoko, Dunn Daniel E, Nishimura Jun-ichi, Kawaguchi Tatsuya, Horikawa Kentaro, Hidaka Michihiro, Kagimoto Tadashi, Eto Nozomu, Mitsuya Hiroaki, Kinoshita Taroh, Young Neal S, Nakakuma Hideki

Abstract excerpt

The cloning of the PIG-A gene has facilitated the unraveling of the complex pathophysiology of paroxysmal nocturnal hemoglobinuria (PNH). Of current major concern is the mechanism by which a PNH clone expands. Many reports have suggested that an immune mechanism operates to cause bone marrow failure in some patients with PNH, aplastic anemia, and myelodysplastic syndromes. Because blood cells of PNH phenotype are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity Tests, Immunologic
Share to Hemoglobinuria, Paroxysmal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to K562 Cells

Share to Killer Cells, Natural

Share to Leukemia

Share to Perforin

Share to Pore Forming Cytotoxic Proteins

Source

Identifiers

PMID: 12130519
DOI: 10.1182/blood.v100.3.1031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.PMID 12130519Read ↗

Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.Semantic proximity Read ↗

Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes.Semantic proximity Read ↗

Glycosylphosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH.Semantic proximity Read ↗

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.Semantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure.Semantic proximity Read ↗

Advances in understanding the pathogenesis of acquired aplastic anaemia.Semantic proximity Read ↗

PIG-A mutations in normal hematopoiesis.Semantic proximity Read ↗

Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

The pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes.Semantic proximity Read ↗

A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.