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Article

The pathophysiology of paroxysmal nocturnal hemoglobinuria.

Experimental hematology - 1 Apr 2007

Parker Charles J

Abstract excerpt

The molecular basis of PNH is known. Somatic mutation of the X-chromosome gene PIGA accounts for deficiency of glycosyl phosphatidylinositol-anchored proteins (GPI-AP) on affected hematopoietic stem cells and their progeny. However, neither mutant PIGA nor the consequent deficiency of GPI-AP prov...

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Topics

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Share to Anemia, Aplastic
Share to Chromosomes, Human, X
Share to Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobinuria, Paroxysmal

Share to Membrane Proteins

Share to Mosaicism

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Source

Identifiers

PMID: 17379062
DOI: 10.1016/j.exphem.2007.01.046

Genes

PIGA
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17379062-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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