Article

Immune pressure on hematopoietic stem cells can drastically expand glycosylphosphatidylinositol-deficient clones in paroxysmal nocturnal hemoglobinuria

2023-09-06

Abstract excerpt

<h4>Background: </h4> Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disease characterized by intravascular hemolysis, thrombosis, and bone marrow (BM) failure. Although PNH is caused by excessive proliferation of hematopoietic stem cell (HSC) clones with loss of function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A ( PIGA ) gene, the factor that drives the expansi...

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Literature Corpus work: cd1bc7ca-b3d9-556f-a17e-e3342c7d39ac
DOI: 10.21203/rs.3.rs-3311505/v1

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