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Article

Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 1999

Araten D J, Nafa K, Pakdeesuwan K, Luzzatto L

Abstract excerpt

In paroxysmal nocturnal hemoglobinuria (PNH), acquired somatic mutations in the PIG-A gene give rise to clonal populations of red blood cells unable to express proteins linked to the membrane by a glycosylphosphatidylinositol anchor. These proteins include the complement inhibitors CD55 and CD59, and this explains the hypersensitivity to complement of red cells in PNH patients, manifested by intravascular...

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Identifiers

PMID: 10220445
DOI: 10.1073/pnas.96.9.5209
PMCID: PMC21843

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