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Article

Paroxysmal nocturnal hemoglobinuria: stem cells and clonality.

Hematology. American Society of Hematology. Education Program - 1 Jan 2008

Brodsky Robert A

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria is a clonal hematopoietic stem cell disease that manifests with intravascular hemolysis, bone marrow failure, thrombosis, and smooth muscle dystonias. The disease can arise de novo or in the setting of acquired aplastic anemia. All PNH patients to date have been shown to harbor PIG-A mutations; the product of this gene is required for the synthesis of...

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PMID: 19074067
DOI: 10.1182/asheducation-2008.1.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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