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Article

Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria.

Frontiers in immunology - 1 Jan 2021

Colden Melissa A, Kumar Sushant, Munkhbileg Bolormaa, Babushok Daria V

Abstract excerpt

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease as simple as it is complex. PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PIGA), required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. Ubiquitous in eukaryotes, GPI anchors are a group of conserved glycolipid molecules responsible for attaching nearly 150...

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Source

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Identifiers

PMID: 35154088
DOI: 10.3389/fimmu.2021.830172
PMCID: PMC8831232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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