Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells.

The American journal of pathology - 1 Oct 2005

Bonello Michelle R, Bobryshev Yuri V, Khachigian Levon M

Abstract excerpt

Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of vascular occlusive disorders such as atherosclerosis and restenosis in part due to its regulation of smooth muscle cell phenotype. The molecular mechanisms regulating the expression of PDGF-Ralpha, which binds all known dimeric forms of PDGF except PDGF-DD, are poorly understood. Here we demonstrate that the winged helix-turn-helix...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arteriosclerosis
Share to Carotid Arteries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

Share to Oxidants

Share to Proto-Oncogene Protein c-ets-1

Share to Rats, Inbred WKY

Share to Receptors, Platelet-Derived Growth Factor

Share to Sp1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 16192649
DOI: 10.1016/s0002-9440(10)61203-5
PMCID: PMC1603673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells.PMID 16192649Read ↗

Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1.Semantic proximity Read ↗

Tyr740 and Tyr751 residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor.Semantic proximity Read ↗

Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.Semantic proximity Read ↗

Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.Semantic proximity Read ↗

Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα.Semantic proximity Read ↗

Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration.Semantic proximity Read ↗

20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.Semantic proximity Read ↗

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein responseSemantic proximity Read ↗

15-Lipoxygenase/15-hydroxyeicosanoid and activator protein 1 contribute to hypoxia-induced pulmonary artery smooth muscle cells phenotype alteration.Semantic proximity Read ↗

Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1.Semantic proximity Read ↗

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.Semantic proximity Read ↗

Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.