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Article

Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.

The Journal of biological chemistry - 3 Jan 2014

Lyle Alicia N, Remus Ebony W, Fan Aaron E, Lassègue Bernard, Walter Grant A, Kiyosue Arihiro, Griendling Kathy K, Taylor W Robert

Abstract excerpt

Recent in vivo studies establish that osteopontin (OPN) expression is hydrogen peroxide (H2O2)-dependent. However, the mechanisms by which H2O2 increases OPN expression remain poorly defined. OPN protein expression increased in an unusual biphasic pattern in response to H2O2. To investigate wheth...

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Identifiers

PMID: 24247243
DOI: 10.1074/jbc.M113.489641
PMCID: PMC3879550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24247243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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