Article
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation.
Development (Cambridge, England) - 1 Oct 2005
Indra Arup Kumar, Dupé Valérie, Bornert Jean-Marc, Messaddeq Nadia, Yaniv Moshe, Mark Manuel, Chambon Pierre, Metzger Daniel
Abstract excerpt
Animal SWI2/SNF2 protein complexes containing either the brahma (BRM) or brahma-related gene 1 (BRG1) ATPase are involved in nucleosome remodelling and may control the accessibility of sequence-specific transcription factors to DNA. In vitro studies have indicated that BRM and BRG1 could regulate the expression of distinct sets of genes. However, as mice lacking BRM are viable and fertile, BRG1 might efficiently...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.