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Article

Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated.

Epigenetics - 1 Feb 2014

Chandler Ronald L, Zhang Ying, Magnuson Terry, Bultman Scott J

Abstract excerpt

Mammalian SWI/SNF-related complexes are recruited to the promoters of numerous target genes, and the BRG1 catalytic subunit confers ATPase activity necessary to slide or evict nucleosomes and to regulate transcription. Based on gene-targeting experiments in mice, BRG1 is essential for early embryonic development. However, Brg1 null mutants have provided limited insight into gene-dosage considerations and...

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Identifiers

PMID: 24172864
DOI: 10.4161/epi.26879
PMCID: PMC3962535

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Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated.PMID 24172864Read ↗

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