Article
Interplay between CDH1 polymorphisms, haplotypes, and genomic repetitive elements in urothelial bladder cancer prognosis.
Molecular biology reports - 23 Jun 2026
Pinheiro Laís Capelasso Lucas, de Souza Martins Maria Alice Feitosa, Turim Maria Fernanda Vicente, da Silva Isabely Mayara, de Oliveira Janaina Nicolau, Terziotti Fernando, Serpeloni Juliana Mara, de Oliveira Karen Brajão, Laforga Vanzela André Luís, Guembarovski Roberta Losi
Abstract excerpt
BACKGROUND: Urothelial Bladder Cancer (UBC) remains a significant clinical challenge due to its high morbidity, substantial economic burden, and high recurrence rates. E-cadherin, an important regulator of cell-cell adhesion encoded by the CDH1 gene, is frequently downregulated during malignant progression, serving as a hallmark of invasiveness. This study explored the prognostic significance of CDH1 genetic...
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