Article
Characterization of DNA polymorphisms in the E-cadherin gene (CDH1) promoter region.
Mutation research - 22 May 2002
Nakamura Akihiro, Shimazaki Tomoe, Kaneko Kazuhiro, Shibata Minoru, Matsumura Takuya, Nagai Maho, Makino Reiko, Mitamura Keiji
Abstract excerpt
E-cadherin is a tumor suppressor involved in epithelial cell-cell interactions. Some of the nucleotide variation in the 5'-promoter region of the gene influences transcriptional efficiency. We investigated single nucleotide polymorphisms (SNPs) in the promoter-exon 1 region of the E-cadherin gene (CDH1) using fluorescence-based PCR-single-strand conformation polymorphism (PCR-SSCP) analysis. We detected four...
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