Article
Mutational and expressional analysis of ERBB3 gene in common solid cancers.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Dec 2014
Choi Mi Ryoung, An Chang Hyeok, Chung Yeun Jun, Choi Youn Jin, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
ERBB3 is a member of EGFR family receptor tyrosine kinases, genetic alterations of which are common and therapeutically targeted in human cancers. Recently, somatic mutations of ERBB3 gene, including recurrent mutation in exon 3 altering Val104, were reported in gastric cancers (GC) and colorectal cancers (CRC), strongly suggesting its role in the development of GC and CRC. To examine whether the recurrent ERBB3...
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