Article
The genetic epidemiology of melanocortin 4 receptor variants.
European journal of pharmacology - 11 Jun 2011
Loos Ruth J F
Abstract excerpt
While rare MC4R mutations are the commonest cause of monogenic forms of extreme, early-onset obesity, growing evidence shows that common MC4R variants contribute to obesity in the general population. Candidate gene studies have focussed on the V103I and I251L MC4R variants that both affect MC(4) receptor function in vitro. Individual association studies, which are typically small and underpowered, have found no...
Topics
- Animals
- Genetic Loci
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Molecular Epidemiology
- Receptor, Melanocortin, Type 4